S. Jin

Phase transition of WTAP regulates m6A modification of interferon-stimulated genes

The paper shows WTAP undergoes phase transition during IFN-β stimulation to regulate m6A modification of ISG mRNAs and control their expression.

Basophils drive the resolution and promote wound healing in adult and aged mice

This study shows basophils promote inflammation resolution and wound healing in both adult and aged mice by driving tissue remodeling and immunoregulatory functions.

Scaffold-enabled high-resolution cryo-EM structure determination of RNA

This paper presents a scaffold strategy to improve cryo-EM resolution for small RNAs, demonstrating high-resolution structures of a TPP riboswitch and its ligand binding dynamics.

Maintenance of haematopoietic stem cells by JAK inhibition and increased tyrosine-unphosphorylated STAT5

This study shows that JAK inhibition increases uSTAT5 levels, which promotes HSC maintenance and stemness, and reveals a new role for uSTAT5 in controlling HSC function.

Primary oocytes with cellular senescence features are involved in ovarian aging in mice

This study shows that senescent primary oocytes contribute to ovarian aging in mice, and their removal improves fertility and follicle numbers.

Structure basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

This study determines the cryo-EM structure of QRFPR bound to 26RFa, revealing the recognition mechanism and aiding drug design for obesity and diabetes.

Dense Sampling of Taxa and Genomes Untangles the Phylogenetic Backbone of a Non-model Plant Lineage Rife with Deep Hybridization and Allopolyploidy

The paper constructs a robust phylogenetic backbone for the Campanuleae tribe using genomic data and phylogenetic methods, revealing hybridization and allopolyploidy as key drivers of diversification.

Tracing the evolution of single-cell cancer 3D genomes: an atlas for cancer gene discovery

The paper maps 3D genome structures in cancer tissues to identify structural changes and potential biomarkers across cancer progression stages.

Structure and dynamics of endogenous protein complexes in human heart tissue captured by native nanoproteomics

This study develops a native nanoproteomics method to characterize the structure and dynamics of endogenous cardiac troponin complexes in human heart tissue using native top-down mass spectrometry.

Biomaterial based implants caused remote liver fatty deposition through activated blood-derived Kupffer cells

Abdominal biomaterial implantation induces remote organ fatty deposition via activated blood-derived Kupffer cells.

EGCG-modified bone graft to modulate the recruitment of M1 macrophage and alleviate the forming of fibrous capsule

This paper modifies bone grafts with EGCG to reduce fibrous capsule formation and improve macrophage recruitment and cell viability.

Deep Learning model accurately classifies metastatic tumors from primary tumors based on mutational signatures

The paper develops a deep learning model that classifies metastatic tumors from primary tumors using mutational signatures from genomic data.

Amyloid beta peptides (Aβ) from Alzheimer's disease neuronal secretome induce endothelial activation in a human cerebral microvessel model

This study shows that Aβ from AD neurons activates endothelial cells, causing inflammation and thrombosis in a human brain microvessel model.

Porous microneedle patch with sustained exosome delivery repairs severe spinal cord injury

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

Injectable hydrogel embedded with mesenchymal stem cells repairs severe spinal cord injury

This study develops an injectable hydrogel with homogenous mesenchymal stem cells to treat severe spinal cord injury in rats, showing improved functional recovery compared to intrathecal delivery.

One-Pot Exosome Proteomics Enabled by a Photocleavable Surfactant

This paper introduces a one-pot exosome proteomics method using a photocleavable surfactant, enabling rapid and effective exosomal lysis, protein extraction, and digestion, with high reproducibility and coverage.

Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry

This study uses top-down mass spectrometry to analyze O-glycoform changes in the Omicron S-RBD variant compared to wild-type and Delta, revealing novel glycosites and structural heterogeneity.

A local translation program regulates centriole amplification in the airway epithelium

This study identifies Tnrc6a as a regulator of centriole amplification and multicilia formation through local translation of miRNA targets in airway epithelial cells.

RNA-CLAMP Enables Photo-activated Control of CRISPR-Cas9 Gene Editing by Site-specific Intramolecular Cross-linking of the sgRNA

RNA-CLAMP enables photo-activated control of CRISPR-Cas9 gene editing by clamping and photo-cleaving sgRNA stem loops to regulate activity.

Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Native Top-Down Mass Spectrometry

This study uses native top-down mass spectrometry to characterize O-glycoforms of the SARS-CoV-2 S-RBD, identifying seven glycoforms and their relative abundance.

Methylation of Dual Specificity Phosphatase 4 Controls Cell Differentiation

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.

Protein Structure Refinement Guided by Atomic Packing Frustration Analysis

This study uses atomic packing frustration analysis to refine predicted protein structures, improving their quality through guided simulations.

DRP1 IS REQUIRED FOR AGRP NEURONAL ACTIVITY AND FEEDING

This study shows that Drp1 is essential for AgRP neuron activity and feeding by regulating mitochondrial fission and fatty acid utilization.

Dissecting the microenvironment around biosynthetic scaffolds in murine skin wound healing

This study investigates how different surface topographies of biomaterial scaffolds affect skin wound healing in mice, finding that aligned scaffolds enhance regeneration and modulate immune responses.

Interleukin-19 alleviates experimental autoimmune encephalomyelitis by attenuating antigen-presenting cell activation

This study shows IL-19 reduces experimental autoimmune encephalomyelitis by inhibiting macrophage activation and Th17 cell expansion, suggesting potential therapeutic use in multiple sclerosis.

A novel and highly effective mitochondrial uncoupling drug in T-cell leukemia

This study shows that MB1-47, a mitochondrial uncoupling compound, effectively inhibits T-ALL cell proliferation and extends survival in mouse models without toxicities.

Multiplexed photo-activation of mRNA with single-cell resolution

This paper demonstrates sequential optical activation of two mRNAs in the same cell using photo-cages, enabling precise control of translation with single-cell resolution.

The mouse Balbiani body maintains primordial follicle quiescence via RNA storage

This study shows the mouse Balbiani body maintains primordial follicle quiescence by storing mRNAs that are translationally inactive and regulated by 5-capping.

Hypothalamic transcriptome analysis reveals the neuroendocrine mechanisms in controlling broodiness of Muscovy duck (Cairina moschata)

The paper analyzes the hypothalamic transcriptome of Muscovy ducks across reproductive stages to identify gene expression changes and pathways involved in broodiness.

Investigation of novel functions of three genes in oriental river prawn, Macrobrachium nipponense: Molecular Cloning, Expression, and In situ Hybridization Analysis

This study investigates the functions of three genes in male sexual development and androgenic gland formation in M. nipponense using molecular cloning, expression analysis, and in situ hybridization.