Gram-positive bacteria secrete RNA aptamers to activate human STING for IL-1β release.
S. N. Duduskar, M. Ghait, M. Westermann, H. Guo, A. Ramoji, C. Sponholz, B. Goehrig, T. Bruns, U. Neugebauer, J. Popp, L. P. N. Tuchscherr, B. Loeffler, N. Ueberschaar, C. Beemelmanns, M. Singer, , S. D. Deshmukh
This study identifies RNA aptamers secreted by Gram-positive bacteria that activate the STING pathway to induce IL-1β release in human macrophages.
bioRxiv · Jul 21, 2021 · PreprintImmunology