Author

B. Hurysz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

E. Boura· 2 shared J. Almaliti· 2 shared L. Eckmann· 2 shared P. Fajtova· 2 shared Y. Miyamoto· 2 shared A. J. O'Donoghue· 1 shared A. O Donoghue· 1 shared C. Caffrey· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiophysics

E. Boura

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2 papers

Recent·Most cited

Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors

J. Silhan, P. Fajtova, J. Bartosova, B. Hurysz, J. Almaliti, Y. Miyamoto, L. Eckmann, W. Gerwick, A. O Donoghue, E. Boura

This study determines the cryo-EM structures of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors, revealing their binding modes and explaining inhibitor specificity.

bioRxiv · Aug 17, 2023 · PreprintBiophysics

Development of subunit selective substrates for Trichomonas vaginalis proteasome

P. Fajtova, B. Hurysz, Y. Miyamoto, M. Serafim, Z. Jiang, D. F. Trujillo, L. J. Liu, U. Somani, J. Almaliti, S. Myers, C. Caffrey, W. H. Gerwick, C. J. Kirk, E. Boura, L. Eckmann, A. J. O'Donoghue

The paper develops three subunit-specific fluorogenic substrates for the T. vaginalis proteasome and identifies effective inhibitor targets.

bioRxiv · Apr 5, 2023 · PreprintBiochemistry