J. Almaliti

This study determines the cryo-EM structures of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors, revealing their binding modes and explaining inhibitor specificity.

This paper develops covalent macrocyclic proteasome inhibitors for Plasmodium falciparum that show reduced resistance compared to reversible inhibitors.

The paper develops three subunit-specific fluorogenic substrates for the T. vaginalis proteasome and identifies effective inhibitor targets.

This study develops highly selective epoxyketone-based proteasome inhibitors effective against Plasmodium falciparum with low cytotoxicity to human cells.