Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors
J. Silhan, P. Fajtova, J. Bartosova, B. Hurysz, J. Almaliti, Y. Miyamoto, L. Eckmann, W. Gerwick, A. O Donoghue, E. Boura
This study determines the cryo-EM structures of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors, revealing their binding modes and explaining inhibitor specificity.
bioRxiv · Aug 17, 2023 · PreprintBiophysics