Author

L. Eckmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Evolutionary Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

B. Hurysz· 2 shared E. Boura· 2 shared J. Almaliti· 2 shared P. Fajtova· 2 shared Y. Miyamoto· 2 shared A. Astvaldsson· 1 shared A. J. A. Molina· 1 shared A. J. O'Donoghue· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

B. Hurysz

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors

J. Silhan, P. Fajtova, J. Bartosova, B. Hurysz, J. Almaliti, Y. Miyamoto, L. Eckmann, W. Gerwick, A. O Donoghue, E. Boura

This study determines the cryo-EM structures of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors, revealing their binding modes and explaining inhibitor specificity.

bioRxiv · Aug 17, 2023 · PreprintBiophysics

Development of subunit selective substrates for Trichomonas vaginalis proteasome

P. Fajtova, B. Hurysz, Y. Miyamoto, M. Serafim, Z. Jiang, D. F. Trujillo, L. J. Liu, U. Somani, J. Almaliti, S. Myers, C. Caffrey, W. H. Gerwick, C. J. Kirk, E. Boura, L. Eckmann, A. J. O'Donoghue

The paper develops three subunit-specific fluorogenic substrates for the T. vaginalis proteasome and identifies effective inhibitor targets.

bioRxiv · Apr 5, 2023 · PreprintBiochemistry

Gnas ablation in CD11c+ cells prevents high-fat diet-induced obesity by elevating adipose tissue catecholamine levels and thermogenesis

L. Zeng, D. S. Herdman, J. Lee, A. Tao, M. Das, S. Bertin, L. Eckmann, S. K. Mahata, S. Devulapalli, H. Patel, A. J. A. Molina, O. Osborn, M. Corr, E. Raz, N. J. G. Webster

bioRxiv · Jan 27, 2022 · PreprintImmunology

Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells

M. R. Spalinger, R. Hai, J. Li, A. N. Santos, T. M. Nordgren, M. L. Tremblay, L. Eckmann, E. Hanson, M. Scharl, X. Wu, B. S. Boland, D. F. McCole

The paper identifies a genetic variant that increases SARS-CoV-2 receptor expression and susceptibility, and shows a JAK inhibitor reduces this risk.

bioRxiv · Dec 9, 2020 · PreprintMicrobiology

The compact genome of Giardia muris reveals important steps in the evolution of intestinal protozoan parasites

F. Xu, A. Jimenez-Gonzalez, E. Einarsson, A. Astvaldsson, D. Peirasmaki, L. Eckmann, J. O. Andersson, S. G. Svärd, J. Jerlström-Hultqvist

This study reports the draft genome of Giardia muris, revealing evolutionary adaptations and metabolic differences compared to Giardia intestinalis.

bioRxiv · Jul 6, 2020Evolutionary Biology