Cancer BiologybioRxivPreprint
Activation of the Integrated Stress Response overcomes multidrug resistance in FBXW7-deficient cells
L. Sanchez-Burgos, B. Navarro-Gonzalez, S. Garcia-Martin…·O. Fernandez-Capetillo
This study shows that FBXW7 deficiency causes multidrug resistance, which can be overcome by targeting mitochondria and activating the Integrated Stress Response.
DOI 10.1101/2022.01.17.476566