Rational design of disordered proteins for systematic sequence-to-function investigation
K. Hunter, T. Brandt, K. Guadalupe, K. C. Kolamunna, J. M. Lotthammer, N. M. Shamoon, B. Nicholson, L. Day, A. Martinez, A. S. Holehouse, S. Sukenik, R. J. Emenecker
This paper introduces GOOSE, a computational framework for designing intrinsically disordered proteins, and demonstrates its ability to create IDRs with specific functional responses.
bioRxiv · Oct 29, 2023 · PreprintBiophysics