J. Ruan

CetZ1-dependent polar assembly of the archaeal motility machinery

This study shows that CetZ1 is essential for the polar assembly of the archaeal motility machinery, with distinct roles from its paralog CetZ2.

MIPDB: A maize image-phenotype database with multi-angle and multi-time characteristics

The paper introduces MIPDB, a maize image-phenotype database with multi-angle and multi-time images, providing a high-quality dataset for deep learning-based phenomics research.

Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer

This study investigates how Vps5 and Vps17 SNX-BAR proteins assemble with Retromer, revealing a PL motif in Vps5 that binds Vps29 and is essential for membrane tubule association and cargo recycling.

Recognition and localization of maize leaves in RGB images based on Point-Line Net

This paper develops Point-Line Net, a deep learning method for detecting maize leaves and roots in field images, achieving 81.5% object detection accuracy and 33.5% keypoint detection performance.

Two subtypes of GTPase-activating proteins coordinate tip growth and cell size regulation in Physcomitrium patens

This study identifies two subtypes of GTPase-activating proteins that regulate tip growth and cell size in moss by modulating ROP activity and membrane organization.

Karyopherin mimicry explains how the HIV capsid penetrates nuclear pores

This paper shows how the HIV capsid mimics karyopherins to penetrate nuclear pores by interacting with FG-motifs, enabling it to bypass the size limit of the nuclear pore complex.

Precision super-resolution cryo-correlative light and electron microscopy for rapid in situ structural analyses of optogenetically-positioned organelles

The paper develops a cryo-CLEM workflow using optogenetics to enable rapid in situ structural analysis of organelles without cryo-focused ion beam milling.

Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells

This study investigates neuroinflammation in neuronopathic Gaucher disease by examining microglia and NK cells in mouse models, showing that Gba rescue in these cells reduces neuroinflammation and improves survival.

Loss of the chromatin remodeler, ATRX, promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin receptor binding

This study shows that loss of ATRX in osteosarcoma promotes aggressive tumor features through NF-κB signaling and integrin receptor binding, suggesting new therapeutic targets.

Blood-brain barrier permeability to enrofloxacin in Pengze crucian carp (Carassius auratus var. Pengze)

This study investigates enrofloxacin's ability to cross the blood-brain barrier in crucian carp and its impact on brain injury markers.

Single-cell chromatin profiling reveals demethylation-dependent metabolic vulnerabilities of breast cancer epigenome

This study uses scATAC-seq to show 2HG enantiomers disrupt DNA and histone demethylation, leading to epigenetic changes in breast cancer cells.

Endometrial Gap Junction Expression - Early Indicators of Endometriosis and Integral to Invasiveness

The paper identifies gap junction expression changes in endometrial cells as indicators of endometriosis and shows their role in lesion invasiveness.

Novel mode of filament formation in UPA-promoted CARD8 and NLRP1 Inflammasomes

This study reports cryo-EM structures of NLRP1-CT and CARD8-CT inflammasome assemblies, revealing unique filament formation mechanisms and ASC recruitment specificity.

Coordinate Enhancer Reprogramming by GATA3 and AP1 Promotes Phenotypic Plasticity to Achieve Breast Cancer Endocrine Resistance

This study identifies GATA3 and AP1-driven enhancer reprogramming as a mechanism promoting phenotypic plasticity and endocrine resistance in breast cancer.

Depression and Anxiety in Healthcare Staffs in A Tertiary University Hospital in Luoyang, Henan Province: A Cross-Sectional Observational Study

This study assesses depression and anxiety prevalence among healthcare staff in a Chinese hospital, identifying workplace violence and poor sleep as key risk factors.

The spermidine acetyltransferase SpeG regulates transcription of the small RNA RprA

This study shows that SpeG, an acetyltransferase, interacts with RcsB to inhibit rprA transcription in E. coli, linking polyamine metabolism to global regulatory functions.

Identification of pyroptosis inhibitors that target a reactive cysteine in gasdermin D

This paper identifies disulfiram and Bay 11-7082 as pyroptosis inhibitors that covalently modify a conserved cysteine in gasdermin D, thereby blocking pore formation and inflammation.

Genetic load and mutational meltdown in cancer cell populations

The paper studies mutational meltdown in HeLa cancer cell populations, finding high rates of deleterious copy number variations and significant fitness reduction per mutation.