K. Hunter

Perivascular adipose tissue remodeling impairs vasoreactivity in thermoneutral-housed rats

This study shows that thermoneutral housing causes perivascular adipose tissue remodeling in rats, leading to sex-dependent impairments in vasoreactivity and mitochondrial function.

The gatekeeper to gastric cancer; gastric microbiota invade the lamina propria in Helicobacter pylori-associated gastric carcinogenesis

This study investigates the spatial organisation of gastric microbiota in health and disease, finding that non-H. pylori bacteria invade the lamina propria in H. pylori-associated gastric carcinogenesis.

SMARCD1 is a "Goldilocks" metastasis modifier

The paper identifies Smarcd1 as a 'Goldilocks' metastasis modifier gene, showing that both high and low expression correlate with better clinical outcomes, while intermediate expression worsens survival in breast cancer.

Loss of NAT10 disrupts enhancer organization via p300 mislocalization and suppresses transcription of genes necessary for metastasis progression.

This study shows that NAT10 loss reduces lung metastasis by disrupting enhancer organization through p300 mislocalization and altering gene transcription related to metastasis.

Rational design of disordered proteins for systematic sequence-to-function investigation

This paper introduces GOOSE, a computational framework for designing intrinsically disordered proteins, and demonstrates its ability to create IDRs with specific functional responses.

Differential Regulation of Retinoic Acid Metabolism in Fanconi Anemia

This study identifies differential regulation of retinoic acid metabolism in Fanconi anemia patient cells, linking retinaldehyde to DNA damage and repair defects.

Metastasis-specific gene expression in autochthonous and allograft mouse mammary tumor models: stratificationand identification of targetable signatures

This study compares metastasis-specific gene expression in different mouse breast cancer models and identifies clinically targetable pathways involved in metastatic spread.

CRK2 and C-terminal phosphorylation of NADPH oxidase RBOHD regulate ROS production in Arabidopsis

This study identifies CRK2 as a regulator of RBOHD-mediated ROS production in Arabidopsis, showing that CRK2 phosphorylates RBOHD's C-terminus to enhance defense against pathogens.

The genomic landscape of metastasis in treatment-naive breast cancer models

This study identifies recurrent mutations and copy number variations as key drivers of metastasis in treatment-naive breast cancer using pre-clinical mouse models.

CRK2 enhances salt tolerance by regulating callose deposition in connection with PLDα1

The paper shows CRK2 enhances salt tolerance in Arabidopsis by regulating endocytosis and callose deposition, working with PLDα1.

Integrated sequence and gene expression analysis of mouse models of breast cancer reveals critical events with human parallels

The paper analyzes genomic and transcriptomic data from mouse breast cancer models to identify genomic events with parallels in human cancers and their functional impacts.

Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific genetic changes associated with immortalisation and malignancy.

This study identifies stage-specific genetic changes in head and neck squamous cell carcinoma progression, highlighting CSMD1 inactivation as a key factor in early carcinogenesis and metastasis.

RCD1 Coordinates Chloroplastic and Mitochondrial Electron Transfer through Interaction with ANAC Transcription Factors

The paper shows RCD1 interacts with ANAC transcription factors to regulate chloroplastic and mitochondrial retrograde signaling via ROS-dependent mechanisms.