Cancer BiologyCell ReportsPeer-reviewed
Single-cell chromatin profiling reveals demethylation-dependent metabolic vulnerabilities of breast cancer epigenome
M. Kusi, M. Zand, C.-L. Lin…·K. Mitsuya
This study uses scATAC-seq to show 2HG enantiomers disrupt DNA and histone demethylation, leading to epigenetic changes in breast cancer cells.
DOI 10.1016/j.celrep.2021.110220