Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer
O. J. Chen, E. Castellsague, M. Moustafa-Kamal, J. Nadaf, B. Rivera, S. Fahiminiya, Y. Wang, I. Gamache, C. Pacifico, L. Jiang, J. Carrot-Zhang, L. Witkowski, A. M. Berghuis, S. Schoenberger, D. Schneider, , J. G. Teodoro
The paper identifies CDC20 missense variants linked to familial cancer, showing they impair SAC binding and promote mitotic slippage.
bioRxiv · Sep 13, 2021Cancer Biology