D. Schneider

Structural plasticity of bacterial ESCRT-III protein PspA in higher-orderassemblies

The paper determines cryo-EM structures of PspA rods and shows how structural plasticity is mediated by conformational changes and protomer contacts.

Structural basis for Vipp1 membrane binding: From loose coats and carpetsto ring and rod assemblies

This study presents cryo-EM structures of Vipp1 interacting with bacterial membranes, revealing curvature-dependent structural transitions and membrane remodeling mechanisms.

Long-term imaging of three-dimensional hyphal development using the ePetri dish

The paper introduces an upgraded ePetri dish system for long-term 3D microbial imaging, demonstrating its ability to monitor hyphal development and detect filter failures.

Targeted intracellular delivery of molecular cargo to hypoxic human breast cancer stem cells

This study demonstrates targeted intracellular delivery of molecular cargo to hypoxic breast cancer stem cells using GlaS, a protein that binds phosphatidylserine and delivers payloads under hypoxic conditions.

Direct and culture-independent detection of low-abundant Clostridioides difficile in environmental DNA via PCR

This paper develops a PCR method to detect low-abundant Clostridioides difficile in environmental samples, revealing biases in strain isolation due to antibiotic-based enrichment.

Pan-genome analysis of six complete Paracoccus type strain genomes from hybrid next generation sequencing

This study analyzes six complete Paracoccus genomes to understand genomic adaptation and diversity across ecological niches.

Phosphatidylserine-exposing medium/large extracellular vesicles: potential cancer biomarkers

This study identifies medium/large extracellular vesicles (m/lEVs) exposing phosphatidylserine (PS) as potential cancer biomarkers, showing higher PS externalization in cancer-derived m/lEVs compared to non-cancerous ones.

Evolution of bacterial persistence to antibiotics during a 50,000-generation experiment in an antibiotic-free environment

This study tracks the evolution of bacterial persistence over 50,000 generations in an antibiotic-free environment, finding that persistence levels can decrease or remain stable despite no environmental changes.

Germline Missense Variants in CDC20 Result in Aberrant Mitotic Progression and Familial Cancer

The paper identifies CDC20 missense variants linked to familial cancer, showing they impair SAC binding and promote mitotic slippage.

Transcriptional Landscape of Ectomycorrhizal Fungi and Their Host Provide Insight into N Uptake from Forest Soil

The paper examines the transcriptional responses of ectomycorrhizal fungi and their host beech tree to nitrogen fluctuations, showing fungal resistance and host dynamic metabolism.

Forest tree species composition and abiotic site conditions drive soil fungal communities and functional groups

The paper investigates how tree species composition and abiotic site conditions influence soil fungal communities and their functional groups in temperate forests.

Metagenomic screening for lipolytic genes reveals an ecology-clustered distribution pattern

The paper screens metagenomes for lipolytic genes using function-driven and sequence-based methods, revealing ecological factors influence their distribution.

Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells

The paper identifies a positive feedback loop between SARS-CoV-2-infected alveolar macrophages and T cells in severe COVID-19 patients, driving persistent alveolitis.

Impact of nitrogen and phosphorus addition on resident soil and root mycobiomes in beech forests

This study examines how nitrogen and phosphorus fertilization affects soil and root mycobiomes in beech forests, finding shifts in fungal community composition and functional potential.

BNT162b vaccines are immunogenic and protect non-human primates against SARS-CoV-2

This paper evaluates two BNT162b vaccine candidates in non-human primates, showing they are immunogenic and protect against SARS-CoV-2 infection.

Mg2+-binding shifts the IM30 activity from membrane protection to membrane destabilization

This study shows that Mg2+ binding to IM30 shifts its activity from membrane stabilization to destabilization, promoting membrane fusion in chloroplasts and cyanobacteria.

PspA adopts an ESCRT-III-like fold and remodels bacterial membranes

This study presents the cryo-EM structure of PspA and shows its ability to remodel bacterial membranes through ESCRT-III-like mechanisms.

IM30 IDPs form a membrane protective carpet upon super-complex disassembly

This study identifies that IM30 forms a membrane-protecting carpet upon super-complex disassembly, revealing a novel mechanism of membrane stabilization by intrinsically disordered proteins.

A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates

This paper reports on a prefusion SARS-CoV-2 spike RNA vaccine that induces strong immune responses and prevents lung infection in non-human primates.

Mechanical Feedback and Robustness of Apical Constrictions in Drosophila Embryo Ventral Furrow Formation

The paper quantitatively analyzes apical constrictions in Drosophila embryos and shows they follow predictions of an active-granular-fluid model, demonstrating robustness through tensile feedback.

Tension causes structural unfolding of intracellular intermediate filaments

The paper uses Raman imaging to show that intracellular vimentin unfolds under cellular tension, indicating IFs act as force sensors.

Fluctuating light experiments and semi-automated plant phenotyping enabled by self-built growth racks and simple upgrades to the IMAGING-PAM

The paper presents a low-cost setup for fluctuating light experiments and improves throughput of the IMAGING-PAM for plant phenotyping.

Bacterial genome architecture shapes global transcriptional regulation by DNA supercoiling

The paper models how DNA supercoiling affects transcription in bacteria and shows that global gene orientation influences supercoiling sensitivity.

Timing of host feeding drives rhythms in parasite replication

This study shows that host feeding rhythms, not central circadian clocks, drive parasite replication timing in malaria, with parasite rhythms aligning to host glucose rhythms and not immune system rhythms.