PhysiologyCirculationPeer-reviewed
Mouse Model of Heart Attack and Stroke Shows Improved Survival with MPO Inhibition
Sohel Shamsuzzaman, Rebecca A. Deaton, Anita Salamon…·Gary K. Owens
The paper introduces a mouse model of advanced atherosclerosis that exhibits spontaneous plaque rupture leading to MI or stroke, and shows that MPO inhibition with AZM198 reduces mortality and plaque rupture incidence.
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