Rebecca A. Deaton

This study uses dual lineage tracing to show irradiation reduces SMC investment in atherosclerotic lesions and increases EC-derived cells, leading to reduced plaque stability.

The paper introduces a mouse model of advanced atherosclerosis that exhibits spontaneous plaque rupture leading to MI or stroke, and shows that MPO inhibition with AZM198 reduces mortality and plaque rupture incidence.

This study shows that inhibiting IL-1β in mice reduces the beneficial effects of diet-induced lipid lowering on atherosclerosis, increasing plaque burden and decreasing plaque stability.