MicrobiologybioRxivPreprint
Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model
Xin Wang, Hongwei Su, Joshua B. Wallach…·Dirk Schnappinger
This paper develops an engineered Mycobacterium tuberculosis strain with kill switches for a safe TB human challenge model, showing rapid clearance and low escape rates.
DOI 10.1101/2023.11.19.567569