Author
Weill Cornell Medicine
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Claire Naylor, Gareth A. Prosser, Tracy Bayliss…·Laura A. T. Cleghorn
The paper identifies and evaluates dibasic piperidines as novel cell wall inhibitors against Mycobacterium tuberculosis, showing activity across multiple media and differential sensitivity in resistant strains.
Qiang Liu, Joshua B. Wallach, Yahani P. Jayasinghe…·Courtney C. Aldrich
The paper develops an orally effective biotin inhibitor, C48, against Mycobacterium tuberculosis, demonstrating in vivo efficacy in a low-biotin mouse model.
William C. Johnson, A. Paul Alivisatos, Trever C. Smith…·Bree B. Aldridge
This study introduces DECIPHAER, a tool that identifies critical mechanisms of tuberculosis drug action by integrating multi-modal data, revealing that respiration inhibition is more impactful than cell wall effects.
Xin Wang, Hongwei Su, Joshua B. Wallach…·Dirk Schnappinger
This paper develops an engineered Mycobacterium tuberculosis strain with kill switches for a safe TB human challenge model, showing rapid clearance and low escape rates.