Author

Xin Wang

Harvard UniversityORCID 0000-0002-6930-3347Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Xin Wang36 papers · 23andMe (United States)

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Eric J. RubiniD· 2 shared Junhao ZhuiD· 2 shared Sarah M. FortuneiD· 2 shared Abigail M FreyiD· 1 shared Benjamin Braunecker· 1 shared Chidiebere AkusobiiD· 1 shared Claudia Maria DenkingeriD· 1 shared David Branch MoodyiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersMicrobiology

Eric J. RubinORCID

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3 papers

Recent·Most cited

MicrobiologyPLoS PathogensPeer-reviewedAug 14, 2026

Encoded metabolic remodeling amplifies drug resistance in Mycobacterium tuberculosis

Abigail M Frey, Gregory H. Babunovic, Peter H. Culviner…·Sarah M. Fortune

This study identifies idsA2 mutations as a mechanism of ethambutol resistance in Mtb by showing they enhance drug resistance through metabolic remodeling.

DOI 10.1371/journal.ppat.1014237

humanwhole-genome sequencing

𝕏 PostBluesky

MicrobiologyPLoS PathogensPeer-reviewedApr 10, 2025

Efflux pumps and membrane permeability contribute to intrinsic antibiotic resistance in Mycobacterium abscessus

Kerry McGowen, Tobias Funck, Xin Wang…·Mark R. Sullivan

The paper identifies membrane permeability and efflux pumps as key mechanisms of intrinsic antibiotic resistance in Mycobacterium abscessus and highlights potential targets for improving antibiotic efficacy.

24 citationstop 1%

humanexperimental assay

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MicrobiologybioRxivPreprintNov 19, 2023

Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model

Xin Wang, Hongwei Su, Joshua B. Wallach…·Dirk Schnappinger

This paper develops an engineered Mycobacterium tuberculosis strain with kill switches for a safe TB human challenge model, showing rapid clearance and low escape rates.

DOI 10.1101/2023.11.19.567569

genetic perturbation / CRISPR

𝕏 PostBluesky