C. A. Castaneda

This study shows that the N-terminal disordered regions and proline-rich domain regulate phase separation in UBQLN1, UBQLN2, and UBQLN4, with distinct temperature dependencies.

This study uses ion mobility mass spectrometry to analyze how protein conformations change during and reverse liquid-liquid phase separation.

This study identifies optimal polyubiquitin ligand architectures that promote UBQLN2 phase separation by analyzing the energetic penalties and spatial configurations of Ub units.

This study investigates how different polyubiquitin chain lengths and linkages affect UBQLN2's liquid-liquid phase separation, showing that extended chains enhance while compact chains inhibit it.

This study identifies previously uncharacterized interactions between folded and disordered domains of UBQLN2 that asymmetrically modulate its phase separation behavior.

This study investigates how ALS-linked mutations in UBQLN2 affect stress-induced biomolecular condensate formation and properties in cells.