TCAIM controls effector T cell generation by preventing Mitochondria-Endoplasmic Reticulum Contact Site-initiated Cholesterol Biosynthesis
C. Iwert, J. Stein, C. Appelt, K. Vogt, R. J. Rainer, K. Tummler, K. Muehle, K. Stanko, J. Schumann, D. Uebe, K. Juerchott, J. Lisec, K. Janek, C. Gille, K. Textoris-Taube, , B. Sawitzki
This study shows TCAIM prevents effector T cell differentiation by inhibiting mitochondria-ER contact sites that drive cholesterol biosynthesis and HIF1 activation.
bioRxiv · Apr 20, 2021 · PreprintImmunology