A. Petersen

Competitive assembly resolves the stoichiometry of essential proteins in infectious HIV-1 virions.

The paper measures the stoichiometry of Gag-Pol and gp120/gp41 proteins in infectious HIV-1 virions using a competitive assembly method, finding it similar to all released virions.

Modeling cellular self-organization in strain-stiffening hydrogels

The paper develops a 3D mathematical model to study cell population dynamics in strain-stiffening hydrogels, showing chain formation and nonlinear mechanical responses under stretching and solvent exchange.

Endogenous Staphylococcus aureus CRISPR-cas system limits phage proliferation and efficiently excises from the genome as part of the SCCmec cassette

This study shows that S. aureus CRISPR-Cas systems, located within SCCmec cassettes, limit phage proliferation but are inefficient, with phages able to escape or overload the system.

Novel determinant of antibiotic resistance: a clinically selected Staphylococcus aureus clpP mutant survives daptomycin treatment by reducing binding of the antibiotic and adapting a rod-shaped morphology

The paper identifies a clpP SNP mutation in MRSA that reduces daptomycin binding and enables survival through rod-shaped morphology, contributing to antibiotic resistance.

Competitive HIV budding suggests that a self-packaging gRNA:Gag-Pol complex directs HIV assembly and enforces infectivity.

The paper investigates HIV assembly by testing infectious/non-infectious genome mixtures, finding that a gRNA:Gag-Pol complex drives virion formation and infectivity.

TCAIM controls effector T cell generation by preventing Mitochondria-Endoplasmic Reticulum Contact Site-initiated Cholesterol Biosynthesis

This study shows TCAIM prevents effector T cell differentiation by inhibiting mitochondria-ER contact sites that drive cholesterol biosynthesis and HIF1 activation.

Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction

The paper identifies mutation-specific pathophysiological mechanisms in SATB1 variants causing distinct neurodevelopmental disorders.

The Sle1 Cell Wall Amidase Controls Daughter Cell Splitting, Cell Size, and β-Lactam Resistance in Community Acquired Methicillin Resistant Staphylococcus aureus USA300

This study identifies Sle1 as a key factor in β-lactam resistance in MRSA USA300, showing that high Sle1 levels promote cell separation and reduce oxacillin sensitivity.

Targeting RET Kinase in Neuroendocrine Prostate Cancer

The paper identifies RET kinase as a targetable driver in neuroendocrine prostate cancer (NEPC) through phosphoproteomics and pharmacological inhibition studies, showing reduced tumor growth in models.

Computational estimation of ms-sec atomistic folding times

The paper estimates atomistic protein folding times using weighted ensemble simulations on GPUs, showing reduced computational cost compared to conventional MD simulations.

Surface tension determines tissue shape and growth kinetics

The paper investigates how surface tension influences tissue shape and growth kinetics, showing that even tissues with extracellular matrices can exhibit fluid-like growth behavior.