Author

J. Lisec

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:metabolomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

C. Jaeger· 2 shared N. Zaidi· 2 shared A. A. Kuehl· 1 shared A. Petersen· 1 shared A. Schramm· 1 shared B. Sawitzki· 1 shared B. Siebers· 1 shared B. Tjaden· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

C. Jaeger

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TCAIM controls effector T cell generation by preventing Mitochondria-Endoplasmic Reticulum Contact Site-initiated Cholesterol Biosynthesis

C. Iwert, J. Stein, C. Appelt, K. Vogt, R. J. Rainer, K. Tummler, K. Muehle, K. Stanko, J. Schumann, D. Uebe, K. Juerchott, J. Lisec, K. Janek, C. Gille, K. Textoris-Taube, , B. Sawitzki

This study shows TCAIM prevents effector T cell differentiation by inhibiting mitochondria-ER contact sites that drive cholesterol biosynthesis and HIF1 activation.

bioRxiv · Apr 20, 2021 · PreprintImmunology

Abundance, fatty acid composition and saturation index of neutral lipids are significantly different between isogenic primary and metastatic colon cancer cell lines

R. Munir, J. Lisec, C. Jaeger, N. Zaidi

This study compares lipid composition between primary and metastatic colon cancer cell lines, finding significant differences in triglyceride and cholesterol ester saturation indices.

bioRxiv · Apr 2, 2020Cancer Biology

MYCN-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma

B. Tjaden, K. Baum, V. Marquardt, M. Simon, M. Trajkovic-Arsic, T. Kouril, B. Siebers, J. Lisec, J. T. Siveke, J. H. Schulte, U. Benary, M. Remke, J. Wolf, A. Schramm

This study shows that MYCN overexpression in neuroblastoma cells rewires metabolism, creating vulnerabilities that can be targeted with metabolic inhibitors.

bioRxiv · Sep 25, 2018Cancer Biology

Cancer cell lipid class homeostasis is altered under nutrient-deprivation but stable under hypoxia

J. Lisec, C. Jaeger, N. Zaidi

The paper examines how cancer cells adjust lipid homeostasis under nutrient-deprivation and hypoxia, finding that lipid class stability is maintained under hypoxia but disrupted under nutrient-deprivation.

bioRxiv · Sep 25, 2018Biochemistry