Evolution of metastases-associated fibroblasts in the lung microenvironment is driven by stage-specific transcriptional plasticity
O. Shani, Y. Raz, L. Monteran, O. Megides, H. Shacham, N. Cohen, D. Silverbush, O. Levi-Galibov, C. Avivi, R. Sharan, A. Madi, R. Scherz-Shouval, I. Barshack, I. Tsarfaty, N. Erez
This study shows lung fibroblasts in breast cancer metastases are transcriptionally dynamic and plastic, with stage-specific gene signatures and Myc as a key regulator linked to poor survival.
bioRxiv · Jul 6, 2020 · PreprintCancer Biology