N. Cohen

An experimental and theoretical approach to understand the interaction between particles and mucosal tissues

This paper investigates how particle size, concentration, and mucin hydrogel properties affect particle-mucus interactions, showing that nanonization improves drug bioavailability and half-life in rats.

Anellovirus Structure Reveals a Mechanism for Immune Evasion

This paper determines the structure of an anellovirus, revealing how its unique surface features enable immune evasion by hiding conserved epitopes and exposing diverse ones as decoys.

A systematic approach to study protein-substrate specificity enables the identification of Ssh1 substrate range

The paper introduces Cel-lctiv, a method to study PPIs in yeast, and demonstrates its use in identifying the unique substrate range of Ssh1.

MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells

This study shows that MERS-CoV's EndoU and accessory proteins NS4a/NS4b together suppress innate immunity, enabling viral replication, unlike SARS-CoV-2 which activates these pathways.

Spatial expression programs of the intestinal follicle-associated epithelium

The paper maps spatial gene expression in intestinal follicle-associated epithelium using RNA sequencing and imaging, revealing zonated expression patterns and distinct cell states.

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial derived cells and cardiomyocytes

This study investigates how SARS-CoV-2 interacts with host antiviral pathways in respiratory and cardiac cells, finding it activates OAS-RNase L and PKR but not IFN, contrasting with MERS-CoV.

Evolution of metastases-associated fibroblasts in the lung microenvironment is driven by stage-specific transcriptional plasticity

This study shows lung fibroblasts in breast cancer metastases are transcriptionally dynamic and plastic, with stage-specific gene signatures and Myc as a key regulator linked to poor survival.

Multiplexed electron microscopy by fluorescent barcoding allows screening for ultrastructural phenotype

The paper introduces a method using fluorescent barcoding and electron microscopy to enable high-throughput screening of ultrastructural phenotypes in yeast.

LINGO3 interacts with Trefoil factor 2 to enforce mucosal barrier integrity and drive tissue repair during colitis

This study identifies LINGO3 as a novel receptor for TFF2 that is essential for maintaining mucosal barrier integrity and tissue repair during colitis.

Spacing of Cue-approach Training Leads to Better Maintenance of Behavioral Change

Spacing cue-approach training over two days improved food preference shifts at one-month follow-up compared to massed training.