Author

A. Pfefferle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Assay:scRNA-seq· 4 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

J. P. Goodridge· 5 shared K.-J. Malmberg· 5 shared S. Lorenz· 4 shared T. Clancy· 4 shared B. Jacobs· 3 shared E. H. Ask· 3 shared E. Sohlberg· 3 shared D. Clement· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersImmunology

J. P. Goodridge

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Author profile →

6 papers

Recent·Most cited

Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping

H. K. Netskar, A. Pfefferle, J. P. Goodridge, E. Sohlberg, O. Dufva, S. Teichmann, T. Clancy, a. horowitz, K.-J. Malmberg

The paper creates a single-cell reference map of NK cells and identifies tumor-associated states predictive of patient outcomes in melanoma and osteosarcoma.

bioRxiv · Oct 26, 2023Immunology

The ratio of exhausted to resident infiltrating lymphocytes is prognostic for colorectal cancer patient outcome

M. Foroutan, R. Molania, A. Pfefferle, C. Behrenbruch, A. Kallies, T. P. Speed, J. Cursons, N. D. Huntington

This study identifies signatures of lymphocyte residency and exhaustion in colorectal cancer using single-cell RNA-seq and shows their association with patient survival outcomes.

bioRxiv · Dec 19, 2020Cancer Biology

A Temporal Transcriptional Map of Human Natural Killer Cell Differentiation

A. Pfefferle, H. Netskar, E. H. Ask, S. Lorenz, J. P. Goodridge, E. Sohlberg, T. Clancy, K.-J. Malmberg

This study maps the transcriptional changes during human NK cell differentiation using single-cell RNA sequencing, identifying key gene programs and checkpoints.

bioRxiv · May 7, 2019 · PreprintImmunology

Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity

A. Pfefferle, B. Jacobs, E. H. Ask, S. Lorenz, T. Clancy, J. P. Goodridge, E. Sohlberg, K.-J. Malmberg

The paper uses flow cytometry and single-cell RNA sequencing to show intra-lineage plasticity and functional reprogramming maintain NK cell repertoire diversity during IL-15-driven homeostasis.

bioRxiv · Jan 9, 2019Immunology

Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal

B. Jacobs, A. Pfefferle, D. Clement, J. P. Goodridge, M. L. Saetersmoen, S. Lorenz, M. T. Wiiger, K.-J. Malmberg

The paper shows that IL-15 withdrawal induces apoptosis in NK cells by increasing BIM short splice variant expression, linked to caspase-3 activation and cell death.

bioRxiv · Aug 17, 2018Immunology

Modulation of Secretory Lysosomes During NK Cell Education Leads to Accumulation of Granzyme B and Enhanced Functional Potential

J. P. Goodridge, B. Jacobs, M. L. Satersmoen, D. Clement, T. Clancy, E. Skarpen, A. Brech, J. Landskron, C. Grimm, A. Pfefferle, L. Meza-Zepeda, S. Lorenz, M. T. Wiiger, W. E. Louch, E. H. Ask, , K.-J. Malmberg

This study shows that NK cell education leads to accumulation of granzyme B in secretory lysosomes, enhancing cytotoxic function through lysosomal Ca2+ signaling and TRPML1 regulation.

bioRxiv · Jul 4, 2018Immunology