C. Behrends

Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival

This study shows that linear ubiquitination at damaged lysosomes activates NF-κB and promotes cell survival through lysophagy.

A ubiquitin-specific, proximity-based labeling approach for the identification of ubiquitin ligase substrates

The paper introduces a proximity-based labeling method to identify ubiquitin ligase substrates and validates it using RAD18, TRAF6, and CHIP.

Mapping of the autophagosomal degradome identifies IL-7Rα as key cargo in proliferating CD4+ T-cells

The paper identifies IL-7Rα as a key autophagosomal cargo in proliferating CD4+ T cells using a transgenic mouse model with LC3 proximity labeling.

Atg4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system

This study reveals that Atg4 family proteins drive autophagosome formation independently of Atg8 lipidation and protease activity, using AI-driven 3D electron microscopy.

ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesis

The paper identifies ACSL3 as an endogenous GABARAPL2 interactor that stabilizes UFM1 conjugation and regulates lipid droplet biogenesis through ER membrane anchoring.

The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy

This study identifies STK38 as a novel inhibitor of BAG3-mediated autophagy, revealing its role in regulating protein homeostasis through interactions with BAG3, HSPB8, and SYNPO2.

LTK is an ER-resident receptor tyrosine kinase that regulates secretion

This study identifies LTK as an ER-resident receptor tyrosine kinase that regulates ER exit sites and ER-to-Golgi transport through interaction and phosphorylation of Sec12.