Author

M. Kaulich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

K. Husnjak· 3 shared I. Dikic· 2 shared M. Wegner· 2 shared A. Ciulli· 1 shared A. Correa-Saez· 1 shared A. D. Cowan· 1 shared A. Ernst· 1 shared A. Gubas· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCell Biology

K. Husnjak

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Targeted protein degradation via intramolecular bivalent glues

O. Hsia, M. Hinterndorfer, A. D. Cowan, K. Iso, T. Ishida, R. Sundaramoorthy, M. A. Nakasone, H. Imrichova, C. Schatz, A. Rukavina, K. Husnjak, M. Wegner, A. Correa-Saez, C. Craigon, R. Casement, , A. Ciulli

This paper introduces intramolecular bivalent glues (IBGs) as a new method for targeted protein degradation, showing they enhance ubiquitination by bridging protein domains and improving degradation efficiency.

bioRxiv · Feb 14, 2023Biochemistry

FBXL4 deficiency promotes mitophagy by elevating NIX.

H. Elcocks, A. J. Brazel, K. R. McCarron, M. Kaulich, K. Husnjak, H. J. Mortiboys, M. J. Clague, S. Urbe

This study identifies FBXL4 as a negative regulator of basal mitophagy through NIX stabilization, showing that its deficiency promotes mitophagy and suggesting MLN4924 as a potential therapeutic agent for mitochondrial diseases.

bioRxiv · Oct 11, 2022 · PreprintCell Biology

Combinatorial CRISPR screening reveals functional buffering in autophagy

V. Diehl, M. Wegner, P. Grumati, K. Husnjak, S. Schaubeck, A. Gubas, V. J. Shah, F. Langschied, A. Kalousi, I. Ebersberger, I. Dikic, M. Kaulich

This study uses combinatorial CRISPR screening to identify gene interactions in autophagy, revealing functional buffering and redundant gene circuits.

bioRxiv · Jul 28, 2020Cell Biology

ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesis

F. Eck, M. Kaulich, C. Behrends

The paper identifies ACSL3 as an endogenous GABARAPL2 interactor that stabilizes UFM1 conjugation and regulates lipid droplet biogenesis through ER membrane anchoring.

bioRxiv · Jan 1, 2020Cell Biology

Novel Conformation Specific Inhibitors of Activated GTPases reveal Ras-dependency of Patient-Derived Cancer Organoids

S. Wiechmann, P. Maisonneuve, B. M. Grebbin, M. Hoffmeister, M. Kaulich, H. Clevers, K. Rajalingam, I. Kurinov, H. F. Farin, F. Sicheri, A. Ernst

The paper develops RBD variants that inhibit Ras effector binding, inducing senescence in non-tumorigenic cells and revealing Ras dependency in cancer organoids.

bioRxiv · Aug 28, 2019Cancer Biology