A. K. Simon

Inheritance of old mitochondria controls early CD8+ T cell fate commitment and is regulated by autophagy

This study shows that autophagy regulates asymmetric inheritance of old mitochondria in CD8+ T cells, which influences their metabolic state and memory potential.

Mapping of the autophagosomal degradome identifies IL-7Rα as key cargo in proliferating CD4+ T-cells

The paper identifies IL-7Rα as a key autophagosomal cargo in proliferating CD4+ T cells using a transgenic mouse model with LC3 proximity labeling.

Adipocyte autophagy limits gut inflammation by controlling oxylipin levels

The paper shows that adipocyte autophagy reduces gut inflammation by regulating oxylipin levels through NRF2-mediated Ephx1 upregulation.

The glycosphingolipid inhibitor eliglustat inhibits autophagy in osteoclasts to increase bone mass and reduce myeloma bone disease

Eliglustat inhibits autophagy in osteoclasts, reducing MM bone disease and suggesting its use as a treatment for bone loss disorders.

Translational control of TFEB and autophagy via eIF5A rejuvenates B cell immunity

This study identifies a mechanism by which spermidine regulates autophagy through eIF5A-mediated TFEB translation, improving B cell immunity in aging.

B1a B cells require autophagy for metabolic homeostasis and self-renewal

This study shows B1a B cells rely on autophagy for metabolic homeostasis and self-renewal, with Atg7 deletion causing their loss due to metabolic dysregulation and mitochondrial dysfunction.