C. Bergonzi

Catalytic Redundancies and Conformational Plasticity Drives Selectivity and Promiscuity in Quorum Quenching Lactonases

This study investigates the catalytic mechanisms and substrate specificity of the lactonase GcL, revealing its promiscuity in reaction mechanisms and broad substrate acceptance.

Identification of the Intracellular Protein Targets of a Bio-active Clickable Half-Sandwich Iridium Complex by Chemical Proteomics

This study identifies intracellular protein targets of a clickable iridium complex using chemical proteomics, revealing dual electrophilic and oxidative stress mechanisms.

Changes in Active Site Loop Conformation Relate to the Transition toward a Novel Enzymatic Activity

The paper redesigns the active site of lactonase SsoPox to enhance phosphotriester catalytic activity, revealing that loop conformation changes are critical for activity shifts.

Field testing of an enzymatic quorum quencher coating additive to reduce biocorrosion of steel

This study evaluates a lactonase enzyme coating to reduce biocorrosion of steel in marine environments, finding it significantly lowers corrosion tubercles and surface area compared to a biocide control.