Linked regulation of genome integrity and senescence-associated inflammation by p53
K. N. Miller, B. Li, H. R. Pierce-Hoffman, S. Patel, X. Lei, A. Rajesh, M. G. Teneche, A. P. Havas, A. Gandhi, C. Cano Macip, J. Lyu, S. G. Victorelli, S.-H. Woo, A. B. Lagnado, M. A. LaPorta, , P. D. Adams
This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.
bioRxiv · Nov 20, 2023 · PreprintCell Biology