MicrobiologybioRxiv
Lathosterol oxidase (sterol C5-desaturase) deletion confers resistance to amphotericin B and sensitivity to acidic stress in Leishmania major
Y. Ning, C. Frankfater, F.-F. Hsu…·K. Zhang
This study shows that deleting LSO in Leishmania major confers amphotericin B resistance but causes sensitivity to acidic stress and membrane disruption.
DOI 10.1128/msphere.00380-20