Author

F.-F. Hsu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell type annotation· 5 Organism:mouse· 5 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

K. Zhang· 4 shared C. Frankfater· 2 shared F. M. Kuhlmann· 2 shared H.-C. Wu· 2 shared K.-H. Liang· 2 shared M. Kumari· 2 shared M. Pawlowic· 2 shared S. Basu· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

K. Zhang

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Dual Membrane-Sspanning Anti-Sigma Factors Regulate Vesiculation in Gut Bacteroidota

E. J. Pardue, M. Sartorio, B. Jana, N. Scott, W. Beatty, J. Ortiz-Marquez, T. van Opijnen, F.-F. Hsu, R. F. Potter, M. Feldman

This study identifies a novel family of Dual Membrane-spanning Anti-sigma factors (Dma) that regulate Outer Membrane Vesicle (OMV) biogenesis in Bacteroides thetaiotaomicron.

bioRxiv · Jul 13, 2023 · PreprintMicrobiology

Ethanolaminephosphate cytidyltransferase is essential for survival, lipid homeostasis and stress tolerance in Leishmania major

S. Basu, M. Pawlowic, F.-F. Hsu, G. Thomas, K. Zhang

This study shows that EPCT is essential for PE synthesis, stress tolerance, and survival in Leishmania major across both promastigote and amastigote stages.

bioRxiv · Jan 10, 2023 · PreprintMicrobiology

Sphingolipids protect ergosterol in the Leishmania major membrane from sterol-binding toxins

C. Haram, S. Moitra, R. Keane, F. M. Kuhlmann, C. Frankfater, F.-f. Hsu, S. M. Beverley, K. Zhang, P. A. Keyel

This study investigates how sphingolipids in Leishmania major protect ergosterol from sterol-binding toxins, showing that ceramide reduces toxin cytotoxicity and enhances amphotericin B efficacy.

bioRxiv · Jun 15, 2022Microbiology

Inositol Phosphorlyceramide Synthase null Leishmania major (Δipcs-) are viable and virulent in animal infections where salvage of host sphingomyelin predominates

F. M. Kuhlmann, P. N. Key, S. M. Hickerson, J. Turk, F.-F. Hsu, S. M. Beverley

This study shows that Leishmania major lacking inositol phosphorlyceramide synthase (IPCS) remains viable and virulent in mice, suggesting SM salvage compensates for IPC loss.

bioRxiv · Jun 14, 2022Microbiology

An Efficient Approach for SARS-CoV-2 Monoclonal Antibody Production via Modified mRNA-LNP Immunization

F.-F. Hsu, K.-H. Liang, M. Kumari, W. Y. Chen, H. T. Lin, C. M. Cheng, M.-H. Tao, H.-C. Wu

This study combines mRNA-LNP immunization with hybridoma fusion to produce SARS-CoV-2 monoclonal antibodies, showing improved antibody titers and cross-variant neutralization.

bioRxiv · Apr 20, 2022Immunology

Broadly neutralizing antibodies against Omicron variants of SARS-CoV-2 derived from mRNA-lipid nanoparticle-immunized mice

R.-M. Lu, K.-H. Liang, H.-L. Chiang, F.-F. Hsu, H.-T. Lin, W.-Y. Chen, F.-Y. Ke, M. Kumari, Y.-C. Chou, H.-C. Wu

This paper develops broadly neutralizing antibodies against Omicron variants of SARS-CoV-2 using mRNA-lipid nanoparticle immunization in mice, showing effectiveness against multiple variants.

bioRxiv · Apr 19, 2022Immunology

De novo synthesis of phosphatidylcholine is essential for the promastigote but not amastigote stage in Leishmania major

S. Moitra, S. Basu, M. Pawlowic, F.-f. Hsu, K. Zhang

This study shows that de novo phosphatidylcholine synthesis via CEPT is essential for promastigote survival but not required for amastigote virulence or replication.

bioRxiv · Dec 30, 2020Microbiology

Lathosterol oxidase (sterol C5-desaturase) deletion confers resistance to amphotericin B and sensitivity to acidic stress in Leishmania major

Y. Ning, C. Frankfater, F.-F. Hsu, R. Soares, C. Cardoso, P. Nogueira, N. Lander, R. Docampo, K. Zhang

This study shows that deleting LSO in Leishmania major confers amphotericin B resistance but causes sensitivity to acidic stress and membrane disruption.

bioRxiv · Apr 20, 2020Microbiology

Direct Binding of Phosphatidylglycerol at Specific Sites Modulates Desensitization of a Pentameric Ligand-Gated Ion Channel

A. Tong, J. T. Petroff, F.-F. Hsu, P. A. Schmidpeter, C. M. Nimigean, L. Sharp, G. Brannigan, W. W. Cheng

The paper shows that phosphatidylglycerol binds to and stabilizes the pentameric ligand-gated ion channel ELIC, reducing desensitization.

bioRxiv · Aug 7, 2019Biophysics