ImmunologybioRxiv
Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity
P.-L. Bernard, R. Delconte, S. Pastor…·G. Guittard
This study shows that deleting CISH enhances NK cell activation and anti-tumor responses in both mice and human cells, suggesting CISH as a therapeutic target for improving NK cell immunotherapy.
DOI 10.1136/jitc-2021-004244