D. Olive

Tertiary lymphoid structures are associated with enhanced macrophage activation, immune checkpoint expression and predict outcome in cervical cancer.

This study shows that tertiary lymphoid structures in cervical cancer are linked to immune activation and better patient outcomes.

Targeting BTN2A1 enhances Vγ9Vδ2 T cell effector functions and triggers tumor cells pyroptosis

Anti-HVEM mAb therapy improves antitumoral immunity both in vitro and in vivo, in a novel transgenic mouse model expressing human HVEM and BTLA molecules challenged with HVEM expressing tumors

Vγ9Vδ2 T cells are potent inhibitors of SARS-CoV-2 replication and exert effector phenotypes in COVID-19 patients

This paper investigates how SARS-CoV-2 affects Vγ9Vδ2 T cells in patients and shows that anti-BTN3A activation enhances their antiviral response.

CD47-SIRPα controls ADCC killing of primary T cells by PMN through a combination of trogocytosis and NADPH oxidase activation.

This study shows anti-CD47 mAbs induce PMN-mediated T cell killing via trogocytosis and NADPH oxidase activation, highlighting the need to consider PMNs in CD47-SIRP checkpoint therapy.

DOK1 and DOK2 regulate CD8+ T cell signaling and memory formation without affecting tumor cell killing

This study shows that DOK1 and DOK2 inhibit CD8+ T cell memory formation but not tumor cell killing, enhancing TCR signaling without improving cytotoxicity.

Endowing Universal CAR T-cell with Immune-Evasive Properties using TALEN-Gene Editing.

This paper develops a novel CAR T-cell scaffold with immune-evasive properties to enable universal allogeneic CAR T-cell therapy.

Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity

This study shows that deleting CISH enhances NK cell activation and anti-tumor responses in both mice and human cells, suggesting CISH as a therapeutic target for improving NK cell immunotherapy.

TNFRSF14 (HVEM) is a novel immune checkpoint for cancer immunotherapy in humanized mice

This study demonstrates that targeting HVEM with a monoclonal antibody inhibits tumor growth in humanized mice by enhancing T cell activity and reducing immunosuppressive pathways.

Monocytes and macrophages, targets of SARS-CoV-2: the clue for Covid-19 immunoparalysis

This study shows SARS-CoV-2 infects monocytes and macrophages, inducing immunoregulatory cytokine secretion and M2-type transcriptional changes, leading to immunoparalysis in Covid-19 patients.

A novel combination of chemotherapy and immunotherapy controls tumor growth in mice with a human immune system

This study shows that combining anti-ICOS mAb with chemotherapy reduces tumor growth in humanized mice by enhancing CD8+ T cell activity and reducing Treg numbers.