Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior protective humoral immune response to SARS-CoV-2
A. Taddeo, I. Berenguer Veiga, C. Devisme, R. Boss, P. Plattet, S. Weigang, G. Kochs, V. Thiel, C. Benarafa, G. Zimmer
This study shows that VSV-vectored spike protein vaccines induce protective immunity when trans-complemented with VSV glycoprotein, but do not achieve sterilizing immunity against SARS-CoV-2.
bioRxiv · Jun 14, 2022 · PreprintImmunology