Author

L. Ulrich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Immunology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:host-pathogen & immune response· 11 Organism:mouse· 9 Organism:rat· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. Beer· 10 shared D. Hoffmann· 9 shared K. Wernike· 6 shared N. J. Halwe· 6 shared A. Breithaupt· 3 shared A. Dorhoi· 3 shared A. Michelitsch· 3 shared A. Taddeo· 3 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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10 shared papersMicrobiology

M. Beer

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Pathogen-prey-predator relations of avian raptors during epizootics of highly pathogenic avian influenza virus HPAIV H5N1 (clade 2.3.4.4b) in Germany

A. Günther, O. Krone, A. Globig, A. Pohlmann, J. King, C. Fast, C. Grund, C. Hennig, C. Herrmann, S. Piro, D. Rubbenstroth, J. Schulz, C. Staubach, L. Stacker, L. Ulrich, , M. Beer

The paper investigates the impact of HPAIV H5N1 on avian raptors during epizootics in Germany, finding they act as both indicators of the virus and victims, with mixed outcomes for their population stability.

bioRxiv · Nov 19, 2023 · PreprintMicrobiology

Mena and VASP are required for vascular smooth muscle relaxation

L. Ulrich, C. Gliem, D. Groneberg, T. Froemel, K. Schuh, I. Fleming, P. M. Benz

This study shows that Mena and VASP are essential for vascular smooth muscle relaxation, with VASP deletion impairing relaxation responses to acetylcholine and nitric oxide.

bioRxiv · Apr 21, 2023 · PreprintPhysiology

Assessment of Immunogenicity and Efficacy of CV0501 mRNA-based Omicron COVID-19 Vaccination in Small Animal Models

N. Roth, J. Gergen, K. Kovacikova, S. Mueller, L. Ulrich, J. Schoen, N. J. Halwe, C. Fricke, B. Corleis, A. Dorhoi, D. Hoffmann, M. Beer, D. Maione, B. W. Petsch, S. Rauch

This paper evaluates the immunogenicity and efficacy of a bivalent mRNA vaccine CV0501 against Omicron subvariants in animal models, showing robust neutralizing antibodies and reduced viral loads.

bioRxiv · Jan 4, 2023Immunology

The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype

T. Barut, N. J. Halwe, A. Taddeo, J. N. Kelly, J. Schön, N. Ebert, L. Ulrich, C. Devisme, S. Steiner, B. S. Trueeb, B. Hoffmann, I. B. Veiga, N. F. G. Leborgne, E. A. Moreira, A. Breithaupt, , V. Thiel

This study shows the spike gene determines replication, pathogenicity, and immune evasion of SARS-CoV-2 Omicron-BA.1 compared to Delta in cell cultures and animal models.

bioRxiv · Apr 28, 2022Microbiology

Low-dose bivalent mRNA vaccine is highly effective against different SARS-CoV-2 variants in a transgenic mouse model

B. Corleis, D. Hoffmann, S. Rauch, C. Fricke, N. Roth, J. Gergen, K. Kovacikova, K. Schlottau, N. J. Halwe, L. Ulrich, J. Schön, K. Wernike, M. Widera, S. Ciesek, S. O. Mueller, , A. Dorhoi

This study shows a low-dose bivalent mRNA vaccine targeting multiple SARS-CoV-2 variants provides strong protection in mice and rats, with comparable antibody levels and reduced viral replication.

bioRxiv · Apr 20, 2022 · PreprintImmunology

Enhanced fitness of SARS-CoV-2 variant of concern B.1.1.7, but not B.1.351, in animal models

L. Ulrich, N. J. Halwe, A. Taddeo, N. Ebert, J. Schön, C. Devisme, B. S. Trüeb, B. Hoffmann, M. Wider, M. Bekliz, M. Essaidi-Laziosi, M. L. Schmidt, D. Niemeyer, V. M. Corman, A. Kraft, , C. Benarafa

The paper compares the fitness of SARS-CoV-2 variants B.1.1.7 and B.1.351 in animal models, finding B.1.1.7 has a fitness advantage in ferrets and mice but not in hamsters.

bioRxiv · Jun 28, 2021Microbiology

CVnCoV protects human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

D. Hoffmann, B. Corleis, S. Rauch, N. Roth, J. Muehe, N. J. Halwe, L. Ulrich, C. Fricke, J. Schoen, A. Kraft, A. Breithaupt, K. Wernike, A. Michelitsch, F. Sick, C. Wylezich, , M. Beer

This study evaluates the efficacy of the CVnCoV mRNA vaccine against ancestral and emerging SARS-CoV-2 variants in a human ACE2 transgenic mouse model, showing complete protection against B.1.351.

bioRxiv · Mar 22, 2021Microbiology

Experimental SARS-CoV-2 infection of bank voles - general susceptibility but lack of direct transmission

L. Ulrich, A. Michelitsch, N. Halwe, K. Wernike, D. Hoffmann, M. Beer

This study shows bank voles become infected with SARS-CoV-2, showing seroconversion and viral RNA, but do not transmit the virus to contact animals.

bioRxiv · Dec 24, 2020 · PreprintMicrobiology

SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility

B. Zhou, T. T. N. Thao, D. Hoffmann, A. Taddeo, N. Ebert, F. Labroussaa, A. Pohlmann, J. King, J. Portmann, N. J. Halwe, L. Ulrich, B. S. Trueb, J. N. Kelly, X. Fan, B. Hoffmann, , M. Beer

This study shows the SARS-CoV-2 D614G variant has enhanced replication and transmissibility in animal models, explaining its global dominance.

bioRxiv · Oct 27, 2020Microbiology

Multi-species ELISA for the detection of antibodies against SARS-CoV-2 in animals

K. Wernike, A. Aebischer, A. Michelitsch, D. Hoffmann, C. Freuling, A. Balkema-Buschmann, A. Graaf, T. Mueller, N. Osterrieder, M. Rissmann, D. Rubbenstroth, J. Schoen, C. Schulz, J. Trimpert, L. Ulrich, , M. Beer

The paper develops a multi-species ELISA to detect SARS-CoV-2 antibodies in animals, achieving 100% specificity and 98.31% sensitivity across multiple species.

bioRxiv · Aug 26, 2020Microbiology

Experimental infection of cattle with SARS-CoV-2

L. Ulrich, K. Wernike, D. Hoffmann, T. C. Mettenleiter, M. Beer

This study infects cattle with SARS-CoV-2 and observes limited replication and sero-reactivity in some animals while in-contact animals remain uninfected.

bioRxiv · Aug 25, 2020Microbiology