MicrobiologybioRxiv
Simulated colonic fluid replicates the in vivo growth capabilities of Citrobacter rodentium cpxRA mutants and uncovers additive effects of Cpx regulated genes on fitness
A. R. Gilliland, C. Gavino, S. Gruenheid, T. L. Raivio
This study shows that C. rodentium cpxRA mutants have reduced colonization and virulence in mice, mirroring their growth defects in simulated colonic fluid, suggesting that multiple Cpx-regulated genes collectively impact fitness.
DOI 10.1128/iai.00314-22