S. Gruenheid

This study identifies LRRK2 as a regulator of the unfolded protein response and antigen presentation in macrophages during inflammation, linking it to immune response mechanisms.

This study shows that C. rodentium cpxRA mutants have reduced colonization and virulence in mice, mirroring their growth defects in simulated colonic fluid, suggesting that multiple Cpx-regulated genes collectively impact fitness.

The study compares the effects of a Mediterranean-like fat blend to other diets in Muc2-/- mice, finding it reduces colitis severity and promotes beneficial gut microbes.

The paper shows that Cpx envelope stress response mutants of Citrobacter rodentium have growth defects in simulated colonic fluid and reduced virulence in mice.

The paper measures OmpT protease activity in UPEC isolates and finds higher activity in symptomatic UTI strains, with some isolates also expressing an additional ompT-like gene, arlC.