J. Wan

SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma

This study identifies SMYD5 as a methyltransferase that modifies RPL40 K22me3, enhancing translation and promoting hepatocellular carcinoma.

Dynamic Single Cell Transcriptomics Defines Kidney FGF23/KL Bioactivity and Novel Segment-Specific Inflammatory Targets

This study uses single-cell transcriptomics to analyze FGF23 bioactivity and identify novel inflammatory targets in the kidney, revealing interactions between FGF23 and TNF/NF-κB pathways.

Functional coexistence theory: a mechanistic framework linking biodiversity to ecosystem function

The paper develops a theoretical framework linking species coexistence to ecosystem function by identifying three components that determine community function.

The under-recognized dominance of magnetosome gene cluster-containing bacteria in oxygen-stratified freshwater ecosystems

The paper identifies a high abundance of magnetosome gene cluster-containing bacteria in oxygen-stratified freshwater environments, revealing Deltaproteobacteria as dominant rather than Magnetococcia.

Morroniside promotes skin wound re-epithelialization by facilitating epidermal stem cell proliferation through GLP-1R-mediated upregulation of β-catenin expression

This study shows that morroniside promotes skin wound healing by enhancing epidermal stem cell proliferation through GLP-1R-mediated upregulation of β-catenin and downstream targets.

Millimeter-scale magnetic implants paired with a fully integrated wearable device for wireless biophysical and biochemical sensing

This paper develops magnetic implants paired with a wearable device to wirelessly measure biophysical and biochemical signals in rats.

The H3.3 K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylation

This study shows that H3.3K36M mutation reduces epigenetic memory and promoter methylation by disrupting the conversion of H3K9me3 domains into DNA methylation.

FLECS Technology for High-Throughput Screening of Hypercontractile Cellular Phenotypes in Fibrosis: A Function-First Approach to Anti-Fibrotic Drug Discovery

This study develops a high-throughput screening platform to identify anti-fibrotic compounds by quantifying myofibroblast contractility in response to TGF-β1.

Targeting Ovarian Cancer Stem Cells by Dual Inhibition of the Long Noncoding RNA HOTAIR and Lysine Methyltransferase EZH2

This study shows that inhibiting HOTAIR and EZH2 reduces ovarian cancer stem cell resistance to platinum chemotherapy and improves survival in vivo.

Molecular imaging with aquaporin-based reporter genes: quantitative considerations from Monte Carlo diffusion simulations

The paper develops a Monte Carlo model to quantify aquaporin-based imaging signals and demonstrates a method to improve specificity by analyzing time-dependent diffusivity changes.

Engineering ligand stabilized aquaporin reporters for magnetic resonance imaging

This paper introduces LSAqp1, a genetically encoded MRI reporter that enables drug-gated, background-free, and multiplex imaging of gene expression in living organisms.

Asparagine starvation suppresses histone demethylation through iron depletion

This study shows asparagine starvation reduces histone demethylation by depleting labile iron, which is essential for JHDMs function, and this effect is mediated through IREB2 and TFRC regulation.

Single Cell Cortical Bone Transcriptomics Defines Novel Osteolineage Gene Sets Altered in Chronic Kidney Disease

The paper defines novel osteolineage gene sets using single-cell transcriptomics and identifies molecular defects in a CKD mouse model.

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate Cancer

This study identifies Pygo2 as a driver oncogene in prostate cancer that suppresses immune infiltration and response to immunotherapy, showing that its inhibition enhances anti-tumor immunity.

McaA and McaB control the dynamic positioning of a bacterial magnetic organelle

This study identifies McaA and McaB as proteins controlling magnetosome chain positioning in Magnetospirillum magneticum AMB-1 through membrane curvature recognition and magnetosome localization.

Crystal Structure of Caskin1/CASK complex reveals the molecular basis of the binding specificity of CASK_CAMK domain and its binding partners

The paper determines the crystal structure of the Caskin1/CASK complex, revealing the molecular basis of CASK_CAMK domain binding specificity and identifying new potential binding partners.

RORA regulates neutrophil migration and activation in zebrafish

This study identifies miR-99 and ROR as regulators of neutrophil migration and anti-microbial defense in zebrafish.

Different mycorrhizal nutrient acquisition strategies shape tree species competition and coexistence dynamics

The paper tests how mycorrhizal strategies and nutrient conditions affect competitive outcomes between ectomycorrhizal and arbuscular mycorrhizal tree species.

A serotonergic axon-cilium synapse drives nuclear signaling to maintain chromatin accessibility

The paper identifies axo-ciliary synapses that mediate serotonin signaling to regulate chromatin accessibility in hippocampal neurons.

Evaluating the feasibility and efficacy of a dual-modality nanoparticle contrast agent (Nanotrast-CF800) for image-guided sentinel lymph node mapping in the oral cavity of healthy dogs

This study evaluates a nanoparticle contrast agent for sentinel lymph node mapping in dogs, showing it effectively identifies SLNs with no adverse effects.

Caspases switch off m6A RNA modification pathway to reactivate a ubiquitous human tumor virus

The paper shows caspases cleave m6A RNA modification components to promote Epstein-Barr virus reactivation.

Magnetotactic bacteria accumulate a large pool of iron distinct from their magnetite crystals

This study quantifies iron pools in Magnetospirillum magneticum AMB-1, showing that magnetite contains at most 30% of total intracellular iron, with a large pool of unmineralized iron detected in the cytoplasm and magnetosomes.

Human IgG neutralizing monoclonal antibodies block SARS-CoV-2 infection

This study identifies potent human neutralizing antibodies against SARS-CoV-2 from convalescent patients, with some showing high efficacy in blocking viral entry.

A single cell atlas of the healthy breast tissues reveal clinically relevant clusters of breast epithelial cells

The paper identifies 13 breast epithelial cell clusters in healthy breast tissues and links some clusters to breast cancer origins and prognosis.

Genome-wide Studies Reveal the Essential and Opposite Roles of ARID1A in Controlling Human Cardiogenesis and Neurogenesis from Pluripotent Stem Cells

This study shows ARID1A has opposite roles in promoting neural differentiation and suppressing cardiac differentiation from human pluripotent stem cells.

Traceback of Core Transcription Factors for Soybean Root Growth Maintenance under Water Deficit

The paper identifies core transcription factors regulating root growth in soybean under water deficit by integrating phylogenetic analysis and transcriptome data.

HeALTH: An Automated Platform for Long-term Longitudinal Studies of Whole Organisms under Precise Environmental Control

The paper introduces HeALTH, an automated microfluidic system for longitudinal behavioral studies of C. elegans under precise environmental control, demonstrating its utility in aging research and beyond.

The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors

This study investigates how HMGB1 and RAGE promote tumor growth in autophagy-deficient livers by altering the tumor microenvironment and mitochondrial function.

Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration

The paper identifies miR-199 as a suppressor of neutrophil migration and inflammation by targeting CDK2, revealing a noncanonical role for CDK2 in cell polarity and chemotaxis.

Inducible overexpression of zebrafish microRNA-722 suppresses chemotaxis of human neutrophil like cells

This study shows that overexpressing zebrafish miR-722 in HL-60 cells reduces chemotaxis and inflammation-related gene expression, suggesting miR-722 suppresses neutrophil migration.