This study identifies a conserved VPS34-PIKfyve-TRPML1-Myosin II axis that controls the speed of amoeboid cell migration by regulating retrograde actin flow through Ca2+ efflux.

bioRxiv · Jan 22, 2024Cell Biology

The non-coding RNA miR-17~92 is a central mediator of T cell activation

M. Doelz, J. D. Gagnon, M. Kornete, R. Marone, G. Bantug, R. Kageyama, C. Hess, K. M. Ansel, D. Seyres, J. Roux, L. T. Jeker

This study identifies miR-17~92 as a central mediator of T cell activation by enhancing the calcineurin/NFAT pathway and repressing negative regulators of activation.

bioRxiv · Oct 13, 2020Immunology

Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells

E. Rivers, R. Rai, J. Lotscher, M. Hollinshead, G. Markelj, J. Thaventheran, A. Worth, A. Cavazza, C. Hess, M. Bajaj-Elliott, A. J. Thrasher

This study shows that WASp deficiency impairs autophagy and mitochondrial function in human myeloid cells, with ARP2/3 dependency and metabolic consequences.

bioRxiv · Feb 6, 2020Physiology

Protection of bona fide T follicular memory cells during tissue isolation reveals their persistence, plasticity and functional impact

M. Künzli, D. P. Schreiner, T. Pereboom, N. Swarnalekha, J. Lötscher, Y. I. Ertuna, J. Roux, F. Geier, C. Hess, J. T. Taylor, C. G. King

This study identifies TFH memory cells as distinct from TCM cells, showing their persistence, plasticity, and functional role in antibody production.

bioRxiv · Jul 7, 2019Immunology