Cell BiologybioRxiv
An evolutionary-conserved VPS34-PIKfyve-TRPML1-Myosin II axis regulates the speed of amoeboid cell migration
P. Dehio, C. Michard, J. C. Yam-Puc…·C. Hess
This study identifies a conserved VPS34-PIKfyve-TRPML1-Myosin II axis that controls the speed of amoeboid cell migration by regulating retrograde actin flow through Ca2+ efflux.