An evolutionary-conserved VPS34-PIKfyve-TRPML1-Myosin II axis regulates the speed of amoeboid cell migration
P. Dehio, C. Michard, J. C. Yam-Puc, A.-A. Marti i Lindez, L. Fabre, T. Schaefer, M. P. Wymann, K. Okkenhaug, T. Soldati, M. Mehling, C. Hess
This study identifies a conserved VPS34-PIKfyve-TRPML1-Myosin II axis that controls the speed of amoeboid cell migration by regulating retrograde actin flow through Ca2+ efflux.
bioRxiv · Jan 22, 2024Cell Biology