Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody-Drug Conjugates
S. Chuprakov, A. O. Ogunkoya, R. M. Barfield, M. Bauzon, C. Hickle, Y. C. Kim, D. Yeo, F. Zhang, D. Rabuka, P. M. Drake
This paper develops tandem-cleavage linkers to improve ADC stability and tolerability, showing better hematopoietic safety in rat studies.
bioRxiv · Jan 19, 2021Pharmacology & Toxicology