Pharmacology & ToxicologybioRxiv
Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody-Drug Conjugates
S. Chuprakov, A. O. Ogunkoya, R. M. Barfield…·P. M. Drake
This paper develops tandem-cleavage linkers to improve ADC stability and tolerability, showing better hematopoietic safety in rat studies.
DOI 10.1021/acs.bioconjchem.1c00029