S. Suresh

ANCHOR : Atlas of Neurochemical Characterization of the Human Brainstem with 3D Reconstruction

ANCHOR provides a detailed human brainstem atlas across three age groups with neurochemical characterization and 3D reconstruction.

Does local adaptation influence thermal responses in red coral populations across depth gradients? Transcriptomic insights for effective conservation.

The paper examines transcriptomic responses to thermal stress in shallow and mesophotic red coral populations, finding distinct gene expression patterns suggesting local adaptation influences thermal resilience.

Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy

This study shows that p63 regulates the balance between squamous and neuroendocrine cell fates in esophageal development and cancer by modulating epigenetic mechanisms.

Structure of Calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A

The paper reports a cryo-EM structure of Calcineurin bound to PI4KA, revealing direct interactions with both PI4KA and FAM126A and their conserved binding sequences.

Emergent Collective Behavior Evolves More Rapidly Than Individual Behavior Among Ant Species

The paper compares evolutionary rates of collective and individual behavior in ants, finding faster and more varied evolution in collective behavior.

Anti-dengue viral activity of Glycyrrhiza glabra roots in Vero cells

This study evaluates the antiviral activity of Glycyrrhiza glabra root extracts against all four dengue serotypes in Vero cells, finding 98-100% inhibition at the maximum nontoxic dose with good selectivity.

Cross-talk between tissues is critical for intergenerational acclimation to environmental change

This study shows that parental exposure to ocean acidification reprograms offspring tissue transcriptomes, enhancing their acclimation to elevated CO2 levels through tissue-specific transcriptional changes.

Zoledronic acid improves bone quality and muscle function in a high bone turnover state

This study shows zoledronic acid improves bone quality and muscle function in a mouse model of metabolic bone disease by reducing TGFβ release from bone.

Low-Magnitude Mechanical Signals Combined with Zoledronic Acid Reduce Musculoskeletal Weakness and Adiposity in Estrogen-Deprived Mice

Combining low-intensity vibration with zoledronic acid reduces musculoskeletal weakness and adiposity in estrogen-deprived mice.

Wolbachia-infected pharaoh ant colonies have higher egg production, metabolic rate, and worker survival

Brain transcriptome of gobies inhabiting natural CO2 seeps reveal acclimation strategies to long-term acidification

The paper examines the brain transcriptome of gobies in natural CO2 seeps to identify molecular acclimation strategies to long-term ocean acidification.

Epigenetic reprogramming of melanoma cell state through fatty acid β-oxidation and Toll like receptor 4 signaling

This study shows that fatty acid β-oxidation and TLR4 signaling drive melanoma progression by altering histone acetylation and inflammatory gene expression.

Modeling the effects of genetic and diet induced obesity on melanoma progression in zebrafish.

The paper develops a zebrafish model to study how genetic and diet-induced obesity affect melanoma progression, finding sex-specific differences in tumor incidence.

Lipid droplets are a metabolic vulnerability in melanoma

This study identifies lipid droplets as a metabolic vulnerability in melanoma by linking the pigmented cell state to increased fatty acid uptake and oxidative metabolism.

Electrical activity between skin cells regulates melanoma initiation

The paper shows GABAergic signaling between keratinocytes and melanoma cells promotes melanoma initiation via BRAFV600E, with electrical activity regulating oncogenic competence.

PRMT1 regulates EGFR and Wnt signaling pathways and is a promising target for combinatorial treatment of breast cancer

This study identifies PRMT1 as a key regulator of EGFR and Wnt signaling in breast cancer and shows that targeting it with inhibitors can enhance chemotherapy and EGFR inhibitor efficacy in TNBC.

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

This study identifies EROS as a chaperone essential for gp91phox maturation and P2X7 receptor function, revealing its role in immune responses and infection resistance.

Do honey bee species differ in the odometer used for the waggle dance?

This study compares the odometer calibration in two honey bee species under different vegetation conditions, finding species-specific responses to visual contrast.

Microgravity modulates effects of chemotherapeutic drugs on cancer cell migration

This study shows microgravity alters cancer cell migration in response to chemotherapy drugs, with daunorubicin showing increased migration in microgravity and doxorubicin showing enhanced migration in both conditions.

Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment

This study shows that β-adrenergic receptor signaling regulates cardiomyocyte cytokinesis, and β-blockers like propranolol can enhance division in ToF/PS cardiomyocytes, potentially improving heart function in CHD patients.

Quantitative multi-locus metabarcoding and waggle dance interpretation reveal honey bee spring foraging patterns in Midwest agroecosystems

The paper uses pollen metabarcoding and waggle dance analysis to study honey bee foraging patterns in agroecosystems, finding key plant taxa and spatial preferences.