PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours
F. Wiede, K.-H. Lu, X. Du, S. Liang, K. Hochheiser, G. Dodd, P. Goh, C. Kearny, D. Meyran, P. Beavis, M. Henderson, S. L. Park, J. Waithman, S. Zhang, Z.-Y. Zhang, , T. Tiganis
This study shows that deleting PTPN2 in T cells improves anti-tumour immunity and CAR T cell effectiveness against solid tumours.
bioRxiv · Sep 5, 2019Immunology