Author

F. Wiede

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

T. Tiganis· 3 shared X. Du· 3 shared K.-H. Lu· 2 shared P. Beavis· 2 shared S. Liang· 2 shared Z.-Y. Zhang· 2 shared C. Kearny· 1 shared C. Xirouchaki· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

T. Tiganis

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3 papers

Recent·Most cited

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

S. Liang, E. Tran, X. Du, J. Dong, H. Sudholz, H. Chen, Z. Qu, N. Huntington, J. Babon, N. Kershaw, Z.-Y. Zhang, J. Baell, F. Wiede, T. Tiganis

This study shows that a PTP1B/PTPN2 inhibitor enhances T cell anti-tumor immunity in mice, improves tumor response to PD1 therapy, and avoids immune-related toxicities.

bioRxiv · Jun 16, 2023 · PreprintCancer Biology

PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity

F. Wiede, K.-H. Lu, X. Du, M. Zessig, R. Xu, P. K. Goh, C. Xirouchaki, S. Hogarth, S. Greatorex, K. Sek, R. Daly, P. Beavis, P. Darcy, N. Tonks, T. Tiganis

This study identifies PTP1B as an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity, showing its deletion or inhibition enhances tumor suppression.

bioRxiv · Nov 11, 2021Cancer Biology

PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours

F. Wiede, K.-H. Lu, X. Du, S. Liang, K. Hochheiser, G. Dodd, P. Goh, C. Kearny, D. Meyran, P. Beavis, M. Henderson, S. L. Park, J. Waithman, S. Zhang, Z.-Y. Zhang, , T. Tiganis

This study shows that deleting PTPN2 in T cells improves anti-tumour immunity and CAR T cell effectiveness against solid tumours.

bioRxiv · Sep 5, 2019Immunology