Activation-induced deaminase is critical for the establishment of DNA methylation patterns prior to the germinal center reaction
F. Catala-Moll, D. Weichenhan, P. Lutsik, A. Alvarez-Prado, J. Rodriguez-Ubreva, C. Klemann, C. Speckmann, H. Abolhassani, M. Martinez-Gallo, R. Dieli-Crimi, P. Soler-Palacin, S. Kracker, L. Hammarstrom, A. Durandy, B. Grimbacher, , E. Ballestar
This study investigates AID's role in DNA methylation defects in HIGM2 B cells, finding that AID is not directly involved in active demethylation but TET enzymes are, and that methylation defects are linked to premature BCR activation.
bioRxiv · Aug 16, 2019Immunology