Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
R. E. Wagner, L. Arnetzl, T. Britto-Borges, A. Heit-Mondrzyk, A. Bakr, E. Sollier, J. Panten, S. Delaunay, D. Sohn, P. Schmezer, D. T. Odom, K. Mueller-Decker, C. Plass, C. Dieterich, P. Lutsik, , M. Frye
This study shows that SRSF2 mutations cause DNA damage and cell cycle arrest, highlighting its role in transcription regulation during cell division.
bioRxiv · Jul 8, 2024Cell Biology
M. Hartmann, M. Schoenung, J. Rajak, V. Maurer, L. Hai, K. Bauer, M. Hakobyan, S. Staeble, J. Langstein, L. Jardine, R. Roelz, S. Bohler, E. Khabirova, A.-H. Maag, D. Vonficht, , D. B. Lipka
This study identifies oncofetal reprogramming in juvenile myelomonocytic leukemia, linking RAS-pathway activation to fetal gene expression and revealing CD52 as a therapeutic target.
bioRxiv · Oct 27, 2023Cancer Biology
D. Weichenhan, A. Riedel, E. Sollier, U. H. Toprak, J. Hey, K. Breuer, J. A. Wierzbinska, A. Touzart, P. Lutsik, M. Baehr, A. Oestlund, C. Nilsson, S. Jacobsson, M. Edler, A. Waraky, , C. Plass
The paper shows MNX1 overexpression in t(7;12)(q36;p13) AML is due to enhancer hijacking, not oncofusion, and is common in pediatric cases.
bioRxiv · Sep 13, 2023 · PreprintCancer Biology
A. Waraky, A. Ostlund, T. Nilsson, D. Weichenhan, P. Lutsik, M. Baehr, J. Hey, J. Adamsson, M. H. A. Morsy, S. Li, L. Fogelstrand, C. Plass, L. Palmqvist
This study identifies MNX1 as a driver of t(7;12)(q36;p13) pediatric AML by altering histone methylation and shows that targeting MNX1 can prevent leukemia development.
bioRxiv · Jun 10, 2022Cancer Biology
Y. Chen, R. Toth, S. Chocarro, D. Weichenhan, J. Hey, P. Lutsik, S. Sawall, G. T. Stathopoulos, C. Plass, R. Sotillo
This study identifies Club cells as a major cell-of-origin for lung adenocarcinoma, revealing two evolutionary trajectories similar to lung regeneration and tumor-specific epigenetic changes.
bioRxiv · Jun 10, 2021 · PreprintCancer Biology
M. Llamazares Prada, E. Espinet, V. Mijosek, U. Schwartz, S. M. Waszak, P. Lutsik, R. Tamas, M. Richter, A. Behrendt, S. Pohl, N. Benz, T. Muley, A. Warth, C. P. Heussel, H. Winter, , R. Z. Jurkowska
This paper develops a cryopreservation workflow for human lung tissue that maintains cell viability and omics profiles, enabling single-cell and bulk sequencing for studying lung diseases.
bioRxiv · Apr 1, 2020Cell Biology
J. A. Wierzbinska, R. Toth, N. Ishaque, K. Rippe, J.-P. Mallm, L. Klett, D. Mertens, T. Zenz, T. Hielscher, M. Seifert, R. Kueppers, Y. Assenov, P. Lutsik, S. Stilgenbauer, P. M. Roessner, , D. B. Lipka
This study introduces Methyl-COOM, a method to identify cell-of-origin and CLL-specific epigenetic aberrations by analyzing DNA methylation patterns.
bioRxiv · Feb 4, 2020Cancer Biology
F. Catala-Moll, D. Weichenhan, P. Lutsik, A. Alvarez-Prado, J. Rodriguez-Ubreva, C. Klemann, C. Speckmann, H. Abolhassani, M. Martinez-Gallo, R. Dieli-Crimi, P. Soler-Palacin, S. Kracker, L. Hammarstrom, A. Durandy, B. Grimbacher, , E. Ballestar
This study investigates AID's role in DNA methylation defects in HIGM2 B cells, finding that AID is not directly involved in active demethylation but TET enzymes are, and that methylation defects are linked to premature BCR activation.
bioRxiv · Aug 16, 2019Immunology