Pharmacologic activation of the mitochondrial phosphoenolpyruvate cycleenhances islet function in vivo
A. Abulizi, R. Stark, R. L. Cardone, S. L. Lewandowski, X. Zhao, T. C. Alves, C. Thomas, C. Kung, B. Wang, S. Siebel, Z. B. Andrews, M. J. Merrins, R. G. Kibbey
This study shows that pharmacologic activation of pyruvate kinase (PK) enhances insulin secretion in preclinical diabetes models by stimulating the mitochondrial phosphoenolpyruvate (PEP) cycle.
bioRxiv · Feb 13, 2020 · PreprintPhysiology